keratan sulfate การใช้

• Keratan sulfate is a heparinoid that is a component of cartilage.
• The basic repeating disaccharide unit within keratan sulfate is-3GlcNAc?1 -.
• These involve accumulation of keratan sulfate.
• The monosaccharide mannose is found within the linkage region of keratan sulfate type I ( KSI ).
• They attach themselves to up to 100 Chondroitin sulfate molecules and up to 50 keratan sulfate glycoaminoglycan chains.
• The metabolic pathways : n-glycan biosynthesis, keratan sulfate biosynthesis, and glycan structures-biosynthesis 1.
• Keratan sulfate proteoglycans ( KSPGs ) are members of the small leucine-rich proteoglycan ( SLRP ) family.
• One of the main functions of the third class of GAGs, keratan sulfates, is the maintenance of tissue hydration.
• Lumican is a major keratan sulfate proteoglycan of the cornea but is ubiquitously distributed in most mesenchymal tissues throughout the body.
• It can have up to four N-linked keratan sulfate chains attached to the core protein within the leucine-rich region.
• It exhibits a bottlebrush structure, in which chondroitin sulfate and keratan sulfate glycosaminoglycan ( GAG ) chains are attached to an extended protein core.
• The metabolic pathways : keratan sulfate biosynthesis, glycosphingolipid biosynthesis-lactoseries, glycan structures-biosynthesis 1, and glycan structures-biosynthesis 2.
• There are four N-linked sites within the leucine-rich repeat domain of the protein core that can be substituted with keratan sulfate.
• Unlike HSGAGs and CSGAGs, the third class of GAGs, those belonging to keratan sulfate types, are driven towards biosynthesis through particular protein sequence motifs.
• The metabolic pathways : keratan sulfate biosynthesis, glycosphingolipid biosynthesis-neo-lactoseries, glycan structures-biosynthesis 1, and glycan structures-biosynthesis 2.
• There is an age-dependent decline in the synthesis of keratan sulfate chains, so non-glycated forms of fibromodulin can accumulate in tissues such as cartilage.
• Within the normal cornea, dermatan sulfate is fully hydrated whereas keratan sulfate is only partially hydrated suggesting that keratan sulfate may behave as a dynamically controlled buffer for hydration.
• Within the normal cornea, dermatan sulfate is fully hydrated whereas keratan sulfate is only partially hydrated suggesting that keratan sulfate may behave as a dynamically controlled buffer for hydration.
• According to one tissue analysis performed after corneal transplantation, the sulfation pattern of keratan sulfate proteoglycans in the affected area is typical for corneal rather than scleral tissue . < ! --
• Disaccharides within the repeating region of KSII may be fucosylated and N-Acetylneuraminic acid caps the end of all keratan sulfate type II ( KSII ) chains and up to 70 % of KSI type chains.